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Biaxen (Clarithromycin) is a semi- synthetic macrolide antibiotic chemically related to erythromycin. It is effective against a wide variety of bacteria organisms, such as Haemophilus influenza, Streptococcus pneumoniae, Mycoplasma pneumoniae, Staphylococcus aureus, and mycobacterium avium, and many others.

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Uses

Clarithromycin is used to treat a wide variety of bacterial infections. This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. It may also be used to prevent certain bacterial infections. Clarithromycin is a macrolide antibiotic that works by stopping the growth of bacteria. This antibiotic only treats bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to take

Take Biaxin by mouth with or without food.
Biaxin works best if it is taken at the same time each day.
Continue to take Biaxin even if you feel well. Do not miss any doses.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Abnormal taste; diarrhea; headache; indigestion; nausea; stomach discomfort; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; decreased urination; depression; emotional or mood changes; hallucinations; nightmares; severe diarrhea; severe stomach pain/cramps; trouble sleeping.

Precaution

Before taking clarithromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (e.g., erythromycin, azithromycin); or if you have any other allergies. This medication should be used with caution if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: liver or kidney disease, certain heart problems (e.g., QTc prolongation, bradycardia), mineral imbalance (e.g., low potassium or magnesium levels), family history of certain heart rhythm disorders (QTc prolongation). This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Based on information for similar drugs, this medication may pass into breast milk. Therefore, consult your doctor before breast-feeding.

Drug interactions

Clarithromycin should be avoided by patients known to be allergic to clarithromycin or other chemically similar macrolide antibiotics, such as erythromycin. Clarithromycin can significantly increase blood levels of the active metabolite of terfenadine (Seldane) when these two medications are co-administered. Erythromycin, another macrolide antibiotic structurally similar to clarithromycin, has been known to interact with astemizole (Hismanal), loratadine (Claritin), bromocriptine, warfarin (Coumadin), carbamazepine (Tegretol), cyclosporine, digoxin (Lanoxin), disopyramide (Norpace), ergotamine, lovastatin (Mevacor), phenytoin (Dilantin), theophylline, triazolam (Halcion), and valproate to alter the blood levels of these medicines. Whether clarithromycin can interfere similarly with these medications is not clearly established. Treatment with clarithromycin and other antibiotics can alter normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria responsible for pseudomembranous colitis. Patients who develop pseudomembranous colitis as a result of antibiotics treatment can experience diarrhea, abdominal pain, fever, and sometimes even shock. Safe use with children has not been established. It is not habit forming.

Missed dose

If you miss a dose of clarithromycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Tablets and suspension should be stored at room temperature in a tightly closed container. The oral suspension should not be refrigerated.